Symbol
Name
ID

Gfi1b
growth factor independent 1B
MGI:1276578

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal bleeding

Epistaxis

Gastrointestinal hemorrhage

Menorrhagia

Prolonged bleeding following procedure

Prolonged bleeding time

Bruising susceptibility

Ecchymosis

Petechiae

Myelofibrosis

Increased RBC distribution width

Reduced prothrombin consumption

Reduced quantity of Von Willebrand factor

Reduced von Willebrand factor activity

Abnormality of thrombocytes

Impaired collagen-induced platelet aggregation

Impaired epinephrine-induced platelet aggregation

Impaired thrombin-induced platelet aggregation

Thrombocytopenia

Macrothrombocytopenia

Abnormal number of alpha granules

Absence of alpha granules

Myelodysplasia

Splenomegaly

Disease(s) Associated with GFI1B

gray platelet syndrome

platelet-type bleeding disorder 17

Mouse Phenotypes

hematopoietic system phenotype

abnormal megakaryocyte differentiation

abnormal embryonic erythropoiesis

abnormal blood cell morphology/development

abnormal erythropoiesis

anemia

abnormal bone marrow cell morphology/development

absent erythroid progenitor cell

abnormal megakaryocyte progenitor cell morphology

decreased erythrocyte cell number

absent erythrocytes

decreased hemoglobin content

decreased neutrophil cell number

thrombocytopenia

absent platelets

increased lymphocyte cell number

increased hematopoietic stem cell number

abnormal embryonic erythrocyte morphology

increased splenocyte number

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Gfi1b^tm1Sho/Gfi1b^tm1Sho

Gfi1b^tm1Tmo/Gfi1b^tm1Tmo

Gfi1b^{tm1b(EUCOMM)Hmgu}/Gfi1b⁺

Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho
Tg(Mx1-cre)1Cgn/0 (conditional)

Col1a1^{tm1(tetO-cre)Haho}/?
Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho (conditional)

Gfi1b^tm2Tmo/Gfi1b^tm2Tmo
Tg(Mx1-cre)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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